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1.
Effects of gut microbiome and obesity on the development, progression and prevention of cancer (Review).
Kumavath, R, Pavithran, H, Paul, S, Anju, VT, Busi, S, Dyavaiah, M
International journal of oncology. 2024;(1)
Abstract
Cancer is one of the leading causes of death worldwide and it is estimated that the mortality rate of cancer will increase in the coming years. The etiology of the development and progression of cancer is multifactorial. Insights have been gained on the association between the human microbiome and tumor cell malignancy. A number of commensal microbe species are present in the human gut. They serve pivotal roles in maintaining several health and disease conditions, such as inflammatory bowel disease, irritable bowel syndrome, obesity and diabetes. Known major factors involved in cancer development include age, hormone levels, alcohol consumption, diet, being overweight, obesity, and infections, regardless of the type of cancer. Therefore, the present review aims to discuss the relationship between the gut microbiome and obesity‑associated malignancies, including colorectal, gastric and liver cancer. Obesity has been reported to contribute to the development of numerous types of cancer primarily caused by high fatty food intake. In addition, obesity‑associated microbiome alterations can lead to cancer and its progression. Dysbiosis of the gut microbiota can alter the metabolite profile, whilst increasing the levels of toxins, such as Bacteroides fragilis toxin and colibactin and cytolethal distending toxin, which are responsible for oncogenesis. The present review provides insights into the impact of gut microbiome dysbiosis on the progression of different types of cancers associated with obesity. It also discusses possible strategies for preserving a healthy gut microbiome. Different pre‑clinical and clinical models are available for studying cancer development downstream of gut microbiome dysbiosis. Furthermore, the role of metabolites or drugs employed in colorectal, gastric and liver cancer therapy would be discussed.
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2.
Fatty Acids and their Proteins in Adipose Tissue Inflammation.
Mallick, R, Basak, S, Das, RK, Banerjee, A, Paul, S, Pathak, S, Duttaroy, AK
Cell biochemistry and biophysics. 2024;(1):35-51
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Abstract
Chronic low-grade adipose tissue inflammation is associated with metabolic disorders. Inflammation results from the intertwined cross-talks of pro-inflammatory and anti-inflammatory pathways in the immune response of adipose tissue. In addition, adipose FABP4 levels and lipid droplet proteins are involved in systemic and tissue inflammation. Dysregulated adipocytes help infiltrate immune cells derived from bone marrow responsible for producing cytokines and chemokines. When adipose tissue expands in excess, adipocyte exhibits increased secretion of adipokines and is implicated in metabolic disturbances due to the release of free fatty acids. This review presents an emerging concept in adipose tissue fat metabolism, fatty acid handling and binding proteins, and lipid droplet proteins and their involvement in inflammatory disorders.
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3.
An Insight into the Combination of Probiotics and their Implications for Human Health.
Hmar, EBL, Paul, S, Sharma, HK
Endocrine, metabolic & immune disorders drug targets. 2024;(1):1-12
Abstract
Over 100-1000 microbial species reside in the human gut, where they predominantly influence the host's internal environment and, thus, have a significant impact on host health. Probiotics are best characterized as a microbe or a group of microbes that reside in the gut and support the body's internal microbiota. Probiotics are linked to increased health advantages, including better immune function, improved nutritional absorption, and protection against cancer and heart-related illnesses. Several studies have demonstrated that combining probiotics from different strains with complementary activities may have synergistic advantages and aid in re-establishing the equilibrium of how immunological niches and microorganisms interact. Another thing to remember is that even though a product contains more probiotic strains, that doesn't always guarantee that the health benefits will be more significant. For specific combinations to be justified, there must be clinical proof. The clinical results of a probiotic strain are specifically pertinent to the participants in the relevant research, such as studies on adults or newborn infants. Clinical outcomes of a probiotic strain are mainly connected to the investigated health area (such as gut health, immune health, oral health, etc.). As a result, picking the right probiotic is essential yet tricky because of several factors, including probiotic products with the disease and strain-specific effectiveness exists; however, various probiotic strains have diverse modes of action. The current review focuses on probiotic categorization, their function in enhancing human health, and any potential health benefits of probiotic combinations.
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A shallow water numerical method for assessing impacts of hydrodynamics and nutrient transport processes on water quality values of Lake Victoria.
Paul, S, Reinardy, BTI, D Walakira, D, Bhattacharya, P, Ernstson, H, Kalantari, Z
Heliyon. 2024;(3):e25125
Abstract
Lake Victoria is the world's largest tropical lake and the third-largest water body, providing significant water resources for surrounding environments including the cultural, societal, and livelihood needs of people in its basin and along the White Nile. The aim of this study was to use decade-long time series of measured lake flow in the lake system and phosphorus deposition to develop a suitable numerical model based on shallow water equations (SWE) for assessing water quality in Lake Victoria, an increasingly important tool under climate variation. Different techniques were combined to identify a numerical model that included: i) a high-resolution SWE model to establish raindrop diffusion to trace pollutants; ii) a two-dimensional (2D) vertically integrated SWE model to establish lake surface flow and vertically transported wind speed flow acting on lake surface water by wind stress; and iii) a site-specific phosphorus deposition sub-model to calculate atmospheric deposition in the lake. A smooth (non-oscillatory) solution was obtained by applying a high-resolution scheme for a raindrop diffusion model. Analysis with the vertically integrated SWE model generated depth averages for flow velocity and associated changes in water level profile in the lake system and showed unidirectional whole lake wind blowing from the southwest to northeast. The atmospheric phosphorous deposition model enabled water value assessment for mass balances with different magnitudes of both inflows and outflows demonstrating annual total phosphorus at 13,500 tons concentrating at mid-lake western and eastern parts. The model developed here is simple and suitable for use in assessing flow changes and lake level changes and can serve as a tool in studies of lake bathymetry and nutrient and pollution transport processes. Our study opens towards refining models of complex shallow-water systems.
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5.
Sirolimus-induced Hypertriglyceridemia Leads to Acute Pancreatitis and Diabetic Ketoacidosis Post Stem Cell Transplant for Sickle Cell Disease.
Paul, S, Nirmal, G, Chadha, V, Sharma, R, Kochar, I, Jerath, N, Vohra, R, Kharya, G
Journal of pediatric hematology/oncology. 2024;(1):e91-e93
Abstract
Sirolimus (mammalian target of rapamycin inhibitor) is a potent immunosuppressive agent, used in patients receiving hematopoietic stem cell transplant (HSCT) for Graft vs Host disease prophylaxis. Compared to calcineurin inhibitors, sirolimus has no neurotoxicity or nephrotoxicity, but sirolimus causes dose-dependent thrombocytopenia, leukopenia, delayed wound healing, hyperlipidemia, and hypertriglyceridemia. Here we report a case of acute pancreatitis and diabetic ketoacidosis in a patient with sickle cell disease post haploidentical family donor HSCT which was managed conservatively without plasmapheresis. Based on our review of the literature, this is the first reported case of developing acute pancreatitis as an adverse effect of sirolimus-induced hypertriglyceridemia leading to diabetic ketoacidosis in a recipient of HSCT.
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6.
Exploring the Therapeutic Significance of microRNAs and lncRNAs in Kidney Diseases.
Bravo-Vázquez, LA, Paul, S, Colín-Jurado, MG, Márquez-Gallardo, LD, Castañón-Cortés, LG, Banerjee, A, Pathak, S, Duttaroy, AK
Genes. 2024;(1)
Abstract
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two crucial classes of transcripts that belong to the major group of non-coding RNAs (ncRNAs). These RNA molecules have significant influence over diverse molecular processes due to their crucial role as regulators of gene expression. However, the dysregulated expression of these ncRNAs constitutes a fundamental factor in the etiology and progression of a wide variety of multifaceted human diseases, including kidney diseases. In this context, over the past years, compelling evidence has shown that miRNAs and lncRNAs could be prospective targets for the development of next-generation drugs against kidney diseases as they participate in a number of disease-associated processes, such as podocyte and nephron death, renal fibrosis, inflammation, transition from acute kidney injury to chronic kidney disease, renal vascular changes, sepsis, pyroptosis, and apoptosis. Hence, in this current review, we critically analyze the recent findings concerning the therapeutic inferences of miRNAs and lncRNAs in the pathophysiological context of kidney diseases. Additionally, with the aim of driving advances in the formulation of ncRNA-based drugs tailored for the management of kidney diseases, we discuss some of the key challenges and future prospects that should be addressed in forthcoming investigations.
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7.
Exopolysaccharides from agriculturally important microorganisms: Conferring soil nutrient status and plant health.
Paul, S, Parvez, SS, Goswami, A, Banik, A
International journal of biological macromolecules. 2024;(Pt 2):129954
Abstract
A wide variety of microorganisms secretes extracellular polymeric substances or commonly known as exopolysaccharides (EPS), which have been studied to influence plant growth via various mechanisms. EPS-producing microorganisms have been found to have positive effects on plant health such as by facilitating nutrient entrapment in the soil, or by improving soil quality, especially by helping in mitigating various abiotic stress conditions. The various types of microbial polysaccharides allow for the compartmentalization of the microbial community enabling them to endure undressing stress conditions. With the growing population, there is a constant need for developing sustainable agriculture where we could use various PGPR to help the plant cope with various stress conditions and simultaneously enhance the crop yield. These polysaccharides have also found application in various sectors, especially in the biomedical fields, manifesting their potential to act as antitumor drugs, play a significant role in immune evasion, and reveal various therapeutic potentials. These constitute high levels of bioactive polysaccharides which possess a wide range of implementation starting from industrial applications to novel food applications. In this current review, we aim at presenting a comprehensive study of how these microbial extracellular polymeric substances influence agricultural productivity along with their other commercial applications.
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8.
Helicobacter pylori attachment-blocking antibodies protect against duodenal ulcer disease.
Bugaytsova, JA, Moonens, K, Piddubnyi, A, Schmidt, A, Edlund, JO, Lisiutin, G, Brännström, K, Chernov, YA, Thorel, K, Tkachenko, I, et al
bioRxiv : the preprint server for biology. 2023
Abstract
The majority of the world population carry the gastric pathogen Helicobacter pylori. Fortunately, most individuals experience only low-grade or no symptoms, but in many cases the chronic inflammatory infection develops into severe gastric disease, including duodenal ulcer disease and gastric cancer. Here we report on a protective mechanism where H. pylori attachment and accompanying chronic mucosal inflammation can be reduced by antibodies that are present in a vast majority of H. pylori carriers. These antibodies block binding of the H. pylori attachment protein BabA by mimicking BabA's binding to the ABO blood group glycans in the gastric mucosa. However, many individuals demonstrate low titers of BabA blocking antibodies, which is associated with an increased risk for duodenal ulceration, suggesting a role for these antibodies in preventing gastric disease.
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9.
A Comparative Analysis of Heavy Metal Effects on Medicinal Plants.
Mukherjee, S, Chatterjee, N, Sircar, A, Maikap, S, Singh, A, Acharyya, S, Paul, S
Applied biochemistry and biotechnology. 2023;(4):2483-2518
Abstract
Popularity of herbal drugs has always been in high demand, but recently it has been increasing all over the world, especially in India, because of the lower range of adverse health effects as compared to synthetic or man-made drugs. Not only this but their cost-effectiveness and easy availability to the poor people and the masses, particularly in developing countries, are major causes for their demand. But there lies a huge problem during the process of plant collection that affects their medicinal properties to certain degrees. This is caused by heavy metal toxicity in soil in different locations of the Indian subcontinent. This was correlated with their potential to cause health damage. Exposure of humans to heavy metals includes diverse pathways from food to water to consumption and inhalation of polluted air to permanent damage to exposed skin and even by occupational exposure at workplaces. As we can understand, the main mechanisms of heavy metal toxicity include the production of free radicals to affect the host by oxidative stress, damaging biological molecules such as enzymes, proteins, lipids, and even nucleic acids and finally damaging DNA which is the fastest way to carcinogenesis and in addition, neurotoxicity. Therefore, in this paper, we have researched how the plants/herbs are affected due to heavy metal deposition in their habitat and how it can lead to serious clinical complications.
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10.
Nanocomposite-based smart fertilizers: A boon to agricultural and environmental sustainability.
Chakraborty, R, Mukhopadhyay, A, Paul, S, Sarkar, S, Mukhopadhyay, R
The Science of the total environment. 2023;:160859
Abstract
Fertilizers are indispensable agri-inputs to accomplish the growing food demand. The injudicious use of conventional fertilizer products has resulted in several environmental and human health complications. To mitigate these problems, nanocomposite-based fertilizers are viable alternative options. Nanocomposites, a novel class of materials having improved mechanical strength, barrier properties, and mechanical and thermal stability, are suitable candidates to develop eco-friendly slow/controlled release fertilizer formulations. In this review, the use of different nanocomposite materials developed for nutrient management in agriculture has been summarized with a major focus on their synthesis and characterization techniques, and application aspects in plant nutrition, along with addressing constraints and future opportunities of this domain. Further detailed studies on nanocomposite-based fertilizers are required to evaluate the cost-effective synthesis methods, in-depth field efficacy, environmental fate, stability, etc. before commercialization in the field of agriculture. The present review is expected to help the policy makers and all the stakeholders in the large-scale commercialization and application of nanocomposite-based smart fertilizer products with greater societal acceptance and environmental sustainability in near future.